RxCheck – Drug Interaction API
A replacement for the discontinued NLM Drug Interaction API that checks for harmful interactions between medications. Healthcare apps, pharmacies, and patients need reliable drug interaction data; RxCheck provides this via a simple JSON API with free and paid tiers.
The NLM Drug Interaction API shutdown created a genuine, documented gap that healthcare developers are actively scrambling to fill, making timing unusually concrete rather than speculative. DrugBank offers a competing dataset but targets enterprise pharma at enterprise prices, leaving a clear opening for a developer-friendly, affordable tier. The $2k–10k/mo revenue band is realistic given that even a handful of healthcare SaaS apps or digital pharmacy platforms paying $200–500/mo each gets you there quickly, and API pricing in regulated verticals tends to be sticky once integrated. The biggest risk is liability exposure — any missed or incorrect interaction could result in patient harm, and that reality alone may force costly legal structuring, insurance requirements, or FDA/regulatory scrutiny that kills margins or scares off customers entirely.
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